Social media allows scientists to connect across the globe and across disciplines, share research, discuss innovative ideas, find opportunities, and offer moral support in the form of memes, but the fluid social media landscape can be intimidating and overwhelming for the uninitiated. Scientists and academics looking for an entry point into social media will appreciate this handy PDF guide published in 2020 by the American Chemical Society (ACS) in ACS Central Science, written by Emory University Associate Professor of Chemistry Jennifer M. Heemstra. After a brief explainer on the different platforms such as Facebook, Instagram, LinkedIn, and Twitter, the guide focuses on accessing academic Twitter, which one scientist described as "a huge multidisciplinary, international science meeting that never ends." Aspiring Twitterati will be walked through the process of setting up an account, following other users, and navigating the neverending feed. Ready to engage with the Twitterverse? The guide also covers commenting, posting, retweeting, and other basic engagement functions. Before long, readers' days as Twitter amateurs will be nothing but #TBT (Throwback Thursday).