It’s not hard to see why our readers loved this thought-provoking expose of America’s long history with mind-altering substances. In fact, the ad for Cocaine Toothache Drops (contemporarily priced at 15 cents) alone is worth a trip to this colorful and well curated site. Lesson plans and online activities help educators illustrate how the United States has handled the thin and shifting line between useful medical prescriptions and harmful, illicit substances. Over a century ago, it was not uncommon to find cocaine in treatments for asthma, cannabis offered up as a cure for colds, and other contentious substances offered as medical prescriptions. This engaging collection from the U.S. National Library of Medicine brings together sections on tobacco, alcohol, opium, and marijuana. Visitors can learn about how these substances were marketed and also view a selection of digitized items culled from its voluminous holdings, including advertisements, doctor's prescriptions, and early government documents. In the Education section, educators can look over lesson plans, check out online activities, and explore online resources from the National Institutes of Health, such as, "A Guide to Safe Use of Pain Medicine" and "College Drinking: Changing the Culture.”