Nobel Prize-recipient Paul Berg has made major contributions to the fields of biochemistry and molecular biology for fifty years. This Profiles in Science feature from the National Library of Health contains biographical information on Berg, along with correspondence, laboratory notebooks, portraits, legislative records, reports, and articles related to his work and times. Visitors can start their visit within the site by reading his extended biography, which is divided chronologically into areas like "Protein Synthesis, Tumor Viruses, and Recombinant DNA, 1959-1975". The documents themselves offer a variety of insights into Berg's career, his interactions with other scholars, and the milieu of this type of scientific research over the second half of the twentieth century.