Stirred by Tau, Neurons Amp Up Lipid Droplets in Glia
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
In a small Phase 2 trial, the GLP-1 analogue lixisenatide stabilized motor abilities over one year in people with early PD.
In preliminary studies in five cohorts, the two markers have similar diagnostic accuracy, and stain tangles in postmortem brain equally well.
Two studies describe how small peptides that latch onto tau have an outsize impact on fibrillization of the protein. Both point to therapeutic strategies.
Preclinical studies and early phase trials target microglial receptors CD33 and TREM2, and amyloid-stoking ASC specks.
The neuronal endolysosome system is one of the first to falter in Alzheimer’s disease. What stalls it? C-terminal fragments of amyloid precursor protein disrupting calcium signaling, according to a new study. Cells lacking presenilin 1 and 2 accumulate APP-CTFs in lysosomes at junctions with the endoplasmic reticulum. The CTFs prevent calcium flow from the ER to the lysosome, slowing endolysosomal function.
To support the dynamic demands of neurotransmission, axons require a steady supply of mRNA for local protein synthesis. A new study reports that thousands of these transcripts arrive on lysosomes. If this mode of transport shuts down, local axon translation falters, mitochondria fail, autophagosomes pile up, and axons degenerate.
New in last 7 days
Latest Comments